Propofol Alcohol

Minogue SC, Sun DA. Bacteriostatic saline containing benzyl alcohol decreases the pain associated with the injection of propofol. Anesth Analg 2005 100(3) 683—686. 

A 37-year-old man who had abused metamfetamine, paint thinner, psychotomimetic drugs, and alcohol for 20 years was given chlorpromazine, haloperidol, and fluni-trazepam just before surgery. After spinal anesthesia he was given propofol 5 mg/kg/hour intravenously. However, euphoria and excitement occurred 10 minutes after the start of the infusion and he had excitement, hallucinations, and delirium. His symptoms were suppressed by intravenous haloperidol 5 mg. 

Schnorf H, Landis T. Motor neuron disease after enflurane/ propofol anaesthesia in patient with alcohol abuse. Lancet 1995 346(8978) 850-1. 

Rich JB, Yaster M, Brandt J Anterograde and retrograde memory in children anesthetized with propofol. J Clin Exp Neuropsychol 21 535-546, 1999 Schneider U, Bevalacqua C, Jacobs R, et al Effects of fentanyl and low doses of alcohol on neuropsychological performance in healthy subjects. Neuropsychobiology 39 38-43, 1999... 

C. Propofol may be effective as an adjunct anesthetic agent for refractory alcohol or other sedative-hypnotic withdrawal syndromes and for status epilepti-cus. 

Those who regularly drink alcohol may need more thiopental or propofol than those who do not. In theory, alcohol may increase the risk of renal damage with sevoflurane. It is also probably unsafe to drink for several hours following anaesthesia because of the combined central nervous depressant effects. 

Fassoulaki A, Farinotti R, Servin F, Desmonts JM. CJironic alcoholism increases the induction dose of propofol in humans. Anesth Analg (1993) 77,553-6. 

D-Glucuronic acid is widely distributed in both the plant and animal worlds. In humans, it is an important component of the acidic polysaccharides of connective tissues. The body also uses it to detoxify foreign phenols and alcohols. In the liver, these compounds are converted to glycosides of glucuronic acid (glucuronides), to be excreted in the urine. The intravenous anesthetic propofol (Problem 10.43), for example, is converted to the following water-soluble glucuronide and then excreted in the urine ... 

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