Propargyl alcohol ruthenium carbonyl

Ruthenium hydride complexes such as RuH(Cl)(PPh3)3(tol) (to = toluene) and RuH(Cl)(CO)(PPh3)3 can effect isomerization of propargyl alcohols and propargyl ethers to a,/l-unsaturated carbonyl compound and dienol ether, respectively [13]. 

Redox isomerization. The combination of InCl, and a ruthenium complex in the presence of EtjNH PFg in refluxing THE promotes the conversion of propargylic alcohols to enals and enones. (For enals, the addition ofNHJPF is beneficial.) The process is highly chemoselective, as functionalities such as isolated carbonyl groups, free alcohol, alkyne, and terminal alkene are not affected. 

Nguyen KD, Herkommer D, Krische MJ (2016) Ruthenium-BlNAP-catalyzed alcohol C-H tert-pienylation via 1,3-enyne transfer hydrogenation beyond stoichiometric carbanions in enantioselective carbonyl propargylation. J Am Chem Soc 138 5238-5241... 

The C-C reductive coupling of r-unsaturated compounds with carbonyl electrophiles by ruthenium-catalysed transfer hydrogenation leading to carbonyl allylation, vinylation, and propargylation has been reviewed. The ability of primary alcohols to function both as hydrogen donors and as aldehyde precursors, enabling carbonyl addition directly from the alcohol oxidation level, has been discussed. ... 

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