Propanoyl chloride, 2,2-dimethyl

Dimethylpropanoyl chloride EINECS 221-921-6 Pivaloyl chloride Propanoyl chloride. 2,2-dimethyl- Trimethylacetyl chloride ... 

Hassachusetts. 2,6-Dimethyl phenol and propanoyl chloride were obtained from Aldrich Chemical Company and used without further purification. 

To prove this hypothesis a suitable substrate, l-diazo-3-methyl-3-[(E)-phenyldiazenyl]butan-2-one (42) was used. Methyl 2-(2-arylhydrazino)-2-methylpropanoate (39) reacting with a bulky Grignard reagent like isopropyl magnesium bromide gives 4,4-dimethyl-2-phenyl-l,2-diazeti-din-3-one 40 (87TL6577). Oxidation with ferf-butyl hypochlorite converts diazetidinone 40 into 2-methyl-2-(phenyldiazenyl)propanoyl chloride 41, which upon treatment with diazomethane affords the desired diazo ketone 42 (Scheme 8) (98ACE2229). 

P-Chloropivaloyl chloride 3-Chloro-2,2-dimethylpropanoyl chloride Chloropivaloyl chloride 3-Chloropivaloyl chloride EINECS 224-311-8 NA9263 Propanoyl chloride, 3-chloro-2,2-dimethyl-. 

Massachusetts. 2,6-Dimethyl phenol and propanoyl chloride were obtained from Aldrich Chemical Company and used without further purification. Di isopropyl amine was distilled from calcium hydride prior to use. 2-Methylpropanal was distilled prior to use. 

Besides acetates and benzoates many other types of carboxylic acid esters can be formed, such as chloroacetates, trifluoroacetates, pivalates, carbonates, and thiocarbonates, by reaction with chloroacetic anhydride, trifluoroacetic anhydride, pivaloyl chloride (2,2-dimethyl propanoyl chloride), phosgene or methylchloro-formate, and carbon disulfide or carbonyl sulfide, respectively. Each of the ester derivatives imparts specific chemical properties to the carbohydrates so they can be used selectively in synthetic schemes. It was found that the sulfonic acid esters... 

Examples of C- or N- acylations of the 1,2,6-thiadiazine 1,1-dioxide nucleus are rare. However, acylation of 2,6-dimethyl-4//-l,2,6-thiadiazine-3,5(2H,6//)-dione 1,1-dioxide (140 R = Me) with propionyl chloride in acetonitrile in the presence of triethylamine and magnesium chloride affords the 4-propanoyl derivative (141) (Scheme 10) <89BRP2213145>. 

To a stirred, cooled (0°C) solution of 2.86 g (45 )-4-(phenylmethyl)-3-propanoyl-l,3-oxazolidin-2-one (12.3 mmol) in 100 mL CH2CI2 was added dropwise 1.42 mL titanium(IV) chloride (2.44 g, 12.9 mmol) the mixture was allowed to stir for 5 min. Subsequently, 7.04 mL (-)-sparteine (7.19 g, 30.7 mmol) was added to the yellow slurry. The dark red enolate solution was stirred for 20 min at 0°C before a solution of 4.76 g (3R)-3- [r rf-butyl(dimethyl)silyl]oxy -5-[(4-methoxy-benzyl)oxy]pentanal (13.5 mmol) in 50 mL CH2CI2 was added dropwise, and the mixture was stirred for 1 h at 0°C. The reaction was quenched with 20 mL half-saturated ammonium chloride. After separation of the layers, the organic layer was dried over Na2S04, filtered, and concentrated in vacuo. Purification of the residue by flash chromatography afforded 5.67 g (4R)-4-benzyl-3- (27 ,3R,57 )-5- [ r -butyl(dimethyl)silyl]oxy -3-hydroxy-7-[(4-methoxybenzyl)oxy]-2-methylheptanoyl -l,3-oxazolidin-2-one as a colorless oil, in a yield of 79%. Rf = 0.33 (petroleum ether/Et20, 2 3). 

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