Proline syn-anti Isomerization, Implications for Protein Folding

SCHLEMMINGER, O. WESTERHOFF, W. Saak, J. Martens,/. Chem. Soc. Perkin Trans. 3, 2000, 1867-1871. 

Proline syn-anti Isomerization, Implications for Protein Folding 

Syn-anti isomerization N-terminal to prolyl peptide fragments is one of the rate limiting steps in protein folding [1], Prolyl fragments exist essentially either in the syn or anti form in native proteins, but as an equilibrium 

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