Proline-catalyzed Mannich Reaction Process Development and Optimization

Proline-catalyzed Mannich Reaction Process Development and Optimization 

Despite their high synthetic potential, when L-proline-catalyzed reactions are evaluated, catalytic amounts in the range 20 to 35% and use of excess ketone (usually 20% v/v) represent reaction parameters to be optimized. Experimental studies addressing this issue have been conducted and impressive solutions were found by the List group [23], As a model reaction the Mannich synthesis using p-nitro- 

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