Prolinamine Sulfonamide and Related Catalysts

The utility of ionic liquid conjugate catalysts such as 32 and 33 can be ascribed to their recyclability [195-199]. On the other hand, triazole-based catalysts such as 34 and 35 are readily accessible via Huisgen 1,3-dipolar cycloadditions, so-called click reactions, from azidomethyl-pyrroHdine and acetylenic precursors, and hence make it possible to design new immobilized catalysts [200-207]. 

For example, in 2004, Wang and coworkers reported a series of asymmetric transformations, for example, a-aminoxylahon, Mannich reactions, and a-sulfenylation, under the catalysis of pyrrolidine trifluoromethanesulfonamide 36 the product yields and diastereo- and enanhoselectivities are quite good in most 

Rgure 1.7 Further representative examples of prolinamine sulfonamide organocatalysts. 

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