Progestogens drug administration

One potentially serious consequence of enzyme induction relates to the oral contraceptive pill (OOP), which may be rendered ineffective by induction of its metabolism. The effect of a period of drug administration on circulating concentrations of the appropriate oestrogen and progestogens over the course of menstrual cycles may be examined in women taking the OCP, with additional non-hormonal precautions taken to avoid unwanted pregnancy. 

Amenorrhoea, which refers to the absence of menstruation, is managed by the administration of progestogen components such as dydrogesterone. Nonsteroidal anti-inflammatory drugs are indicated in premenstrual tension. Iron supplements are indicated in menorrhagia (abnormal heavy menstruation). 

VASODILATOR ANTIHYPERTENSIVES -BOSENTAN PROGESTOGENS 1 progesterone levels, which may lead to failure of contraception or poor response to treatment of menorrhagia Possibly induction of metabolism of progestagens Advise patients to use additional contraception for the period of intake and for 1 month after stopping co-administration with these drugs... 

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