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Progabide

The anticonvulsant progabide 24) is useful in a wide variety of seizure disorders. It was synthesiied as a y-aniinobutync acid (GABA) prodrug but its activity appears to reside in the parent drug and its acid metabolite, as well as the GABA liberated [21],... [Pg.1123]

C7H5CIO2 74-11-3) see Bumetanide Clopamide lodamide Progabide Tripamide... [Pg.2323]

C H 5C1N202 13815-59-3) see Indometacin 4-chlorobenzoic acid 4-fluorophcnyl ester (C 3HgClF02 29558-88-1) see Progabide 4-chlorobenzoic acid l-(4-mcthoxyphenyl)hydrazide hydrochloride... [Pg.2323]

C7H4CI2O 122-01-0) see Acemetacin Benoxaprofen Bezafibrate Feclobuzone Fenofibrate Indometacin Moclobemide Progabide Rebamipide Zomepirac (2-chlorobenzoyi)cyciopentane (C12H13CIO 6740-85-8) see Ketamine... [Pg.2324]

Figure 16.7 The structure of some established antiepileptic drugs (AEDs) and some newer ones. Note that while the structures of phenytoin and ethosuximide are similar and also close to that of phenobarbitone, they are effective in different forms of epilepsy. Vigabatrin, progabide and gabapentin are clearly related to GABA. Muscimol is a GABAa agonist but is not an effective antiepileptic drug... Figure 16.7 The structure of some established antiepileptic drugs (AEDs) and some newer ones. Note that while the structures of phenytoin and ethosuximide are similar and also close to that of phenobarbitone, they are effective in different forms of epilepsy. Vigabatrin, progabide and gabapentin are clearly related to GABA. Muscimol is a GABAa agonist but is not an effective antiepileptic drug...
P. Worms, H. Depoortere, A. Durand, R L. Morselli, K. L. Lloyd, G. Barthobni, y-Ami-nobutyric Acid (GABA) Receptor Stimulation. I. Neuropharmacological Profiles of Progabide (SL 76002) and SL 75102, with Emphasis on Their Anticonvulsant Spectra , J. Pharmacol. Exp. Ther. 1982, 220, 660 - 671. [Pg.759]

GABA inhibits the action of the locus ceruleus and this is mediated by the GABAa receptor-chloride channel system. The plasma and cerebrospinal fluid levels of GABA are low, and progabide, a GABAa receptor agonist, has antidepressant properties. [Pg.419]

See other pages where Progabide is mentioned: [Pg.813]    [Pg.537]    [Pg.47]    [Pg.225]    [Pg.245]    [Pg.1717]    [Pg.1717]    [Pg.2290]    [Pg.2330]    [Pg.2334]    [Pg.2387]    [Pg.337]    [Pg.344]    [Pg.595]    [Pg.606]    [Pg.596]    [Pg.607]    [Pg.711]    [Pg.190]    [Pg.346]    [Pg.357]    [Pg.1395]    [Pg.1573]    [Pg.1593]    [Pg.1600]    [Pg.305]    [Pg.344]    [Pg.31]    [Pg.273]    [Pg.273]    [Pg.593]    [Pg.183]    [Pg.813]    [Pg.630]    [Pg.1717]    [Pg.1717]   
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See also in sourсe #XX -- [ Pg.490 ]



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Progabide Phenytoin

Progabide anticonvulsant

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