Profile functional group concept

Several theories relating molecular properties to perceived odor quality have been advanced. Examples include the work of Wright (16,] ) who links odor quality to molecular vibrations in the far-infrared, and of Amoore (18) who links odor quality to molecular shape, size, and electronic nature and who introduced the concept of primary class. Beets (19) has discussed odor quality relative to molecular shape as represented by oriented profiles, chirality, and functional groups. In a recently published book (20) he has expanded these discussions. Theimer and coworkers (, , 23) have discussed the Importance of the molecular cross-sectional areas, free energies of desorption, and chirality in relation to odor. A discussion of musk odor quality and molecular structure has been presented by Teranishi (24). Laffort and coworkers ( ) have related odor quality to four molecular properties derived from gas chromatographic retention indices measured on four stationary phases. 

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