Production of Bacterial Polyhydroxyalkanoates PHAs via Fermentation

Industrial Production of Bacterial Polyhydroxyalkanoates PHAs via Fermentation 

As of now, poly-(/ )-3HB, poly((/ )-3-hydroxybutyrate-co-4-hydroxybutyrate) (P3HB4HB), and PHBV are produced in a large scale. 

Shake flask study 3. Lab and pilot fermentor studies 4. Scale up 

For the bacterial production of PHAs by wild-type strains, the Ralstonia eutropha (formerly called Alcaligenes eutrophus, Wautersia eutropha, or Cupri-avidus necator) has been the most commonly used wild-type strain for the industrial production of PHB, P3HB4HB, and PHBV. 

For the bacterial production of PHAs by recombinant strains, recombinant E. coli has been commonly used for PHA production thanks to its convenience for genetic manipulation, fast growth, high final-cell density, and ability to utilize inexpensive carbon sources. Metabolix and Jiang Su Nan Xian Co. Ltd employed recombinant E. coli for their PHA production. 

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