Product categories, ISPR

Matching the Appropriate ISPR Techniques to Different Product Categories.152... 

A significant number of general reviews on ISPR techniques in whole cell bioprocessing have been published [1,3,14-21]. Furthermore,more specialized reviews exist that cover either a certain product category such as ethanol [4] or butanol [22,23] or the use of certain specialized ISPR techniques such as aqueous two-phase system [24,25], organic-aqueous two-phase systems [26-30],or solid adsorbents [31]. 

Table 1. Appropriate ISPR techniques for different product categories. (+) technique is applicable for selective removal. (++) technique is very useful for selective removal of the product and has shown its effectiveness in several cases...

A total of almost 250 ISPR projects in microbial whole cell biotechnology are listed in Table 2. Over one third of these projects have dealt with the production of organic solvents such as ethanol, butanol, acetone or propanol (90 projects). Ethanol (70% of all the solvents) has been by far the most important microbial product for which different ISPR techniques have been applied. The second most important class of products involved in ISPR projects have been organic acids such as lactic, acetic, butyric, or propionic acid (54 projects). Most of effort in this product class has focused on lactic acid (55% of all organic acids). Important ISPR activities have also been reported for the microbial production of various aromas and fine chemicals (30 projects in each product category). A considerable amount of ISPR approaches have been shown in steroid conversions (17 projects) and the production of secondary metaboHtes and various enzymes (13 projects in each product category). 

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