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Prodrugs research, problems

The above problems appear to be the major sources of difficulty in prodrug research and development, not to mention possible complications during registration. No wonder, therefore, that so many medicinal chemists are critical of prodrugs. However, a lucid view cannot ignore the sunny side, in this case the mere existence of a number of successful prodrugs. Nabume-tone, oseltamivir, and pivampicillin are just a few examples that come to mind. [Pg.27]

B. Testa, J. M. Mayer, Concepts in Prodrug Design to Overcome Pharmacokinetic Problems , in Pharmacokinetic Optimization in Drug Research Biological, Physicochemical, and Computational Strategies , Eds. B. Testa, H. van de Waterbeemd, G. Folk-ers, R. Guy, Verlag Helvetica Chimica Acta, Zurich, 2001, p. 85-95. [Pg.28]

Testa, B. Mayer, J.M. Concepts in prodrug design to overcome pharmacokinetic problems. In Pharmacokinetic Optimization in Drug Research—Biological, Physicochemical and Computational Strategies Testa, B., van de Water-beemd, H., Folkers, G., Guy, R., Eds. Wiley—VCH Weinheim in press. [Pg.3014]

See other pages where Prodrugs research, problems is mentioned: [Pg.3013]    [Pg.567]    [Pg.568]    [Pg.526]    [Pg.3]    [Pg.3008]    [Pg.526]    [Pg.279]    [Pg.301]   
See also in sourсe #XX -- [ Pg.3013 ]



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