Process synthesis mathematical programming

Grossmann, I. E. J. A. Caballero and H. Yeomans. Mathematical Programming Approaches to the Synthesis of Chemical Process Systems. Korean J Chem Eng 16(4) 407-426 (1999). 

P. Floquet, L. Pibouleau, and S. Domenech. Mathematical programming tools for chemical engineering process design synthesis. Chem. Eng. and Proc., 23(2) 99, 1988. 

G. Stephanopoulos. Synthesis of process flowsheets An adventure in heuristic design or a utopia of mathematical programming In R. S. H. Mah and W. D. Seader, editors, Foundations of computer aided process design, volume 2, page 439, New York, 1981. Engineering Foundation. 

A process-synthesis problem can be formulated as a combination of tasks whose goal is the optimization of an economic objective function subject to constraints. Two types of mathematical techniques are the most used mixed-integer linear programming (MILP), and mixed-integer nonlinear programming (MINLP). 

Floquet, P., Pibouleau, L., and Domenach, S. Mathematical Programming Tools for Chemical Engineering Process Design Synthesis, Chem. Eng. Process. 23, 1 (1988). 

Stephanopoulos, G., Synthesis of Process Flowsheets An Adventure in Heuristie Design or a Utopia of Mathematical Programming, in Foundations of Computer-Aided Design, Vol. 2, R. S. H. Mah and W. D. Seider, eds.. Engineering Foundation, p. 439 (1981). 

There are two parts to the design of an optimum process sequence that must be addressed to apply the full power of computers for process design. There must be a mathematical model of the proposed process and there must be a solution to that mathematical model. Most of the process simulators are programmed to solve the mathematical model. The more difficult problem is to program the computer to select the best sequence of process steps from raw materials to products, i.e., process synthesis. 

Grossmann I.E., Caballero J.P. and Yeomans H. 1999. Mathematical programming approaches to the synthesis of chemical process systems, Korean J. Chem. Eng., 16(4), 407-426. 

Grossmann IE, GuiUen-Gosalbez G. Scope for the apphcation of mathematical programming techniques in the synthesis and plarming of sustainable processes. Comput Chem Eng 2010 34(9) 1365-76. 

---