Process Synthesis for the Fluorous Biphasic Hydroformylation of 1-Octene

14 Process Synthesis for the Fluorous Biphasic Hydroformylation of 1-Octene 

To produce 100 000 tonnes of nonanal per year (25% down time, 100% conversion of substrate, 80% selectivity to nonanal) requires a production rate from the reactors of 19 tonne h 1, so that each batch must be 6.3 tonnes. Assuming a 1 1 ratio by volume of fluorous solventdiquid substrate and a 75 % loading, each reactor must have a volume of 20 m3. If the distillation column were fully integrated into the system it would be required to handle 19 tonnes aldehyde h 1. An increase in selectivity to the linear product, which could be achieved using careful ligand design would reduce the reactor size by up to 25%. 

TABLE 6.3. Process for optimized nonanal production of 100 000 tonnes y1 using perfluoro-methylcyclohexane in a fluorous biphasic system a 

Based on 25% down time, perfluorohexane as fluorous solvent and P(4-C6H4C6Fi3)3 as the ligand. 

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