Procedural-related abnormalities

UicAochAornatogAoptiic TcAtcng MetkodA ioA Sickle, Cell Anemia and Related Vl60AdeAA in the AdixJit. The procedures described in the preceding Section are, in fact, applicable to the detection of hemoglobinopathies in the adult, and any quantitative determination of Hb-A2 immediately becomes a qualitative test for abnormal Hb s. If, instead of the very small zone of Hb-A2, a prominent zone moves in the same way, Hb-C (or Hb- ) is indicated. 

In these 500 cases, there were 26 culture failures, an Incidence of about 5% Nine women of this group underwent a second aminocentesls, and successful cultures were obtained The other 17, or 3 4% of the total, did not obtain any results, either because of spontaneous abortions prior to the time a second amniocentesis could be performed (In four) or because the family elected not to proceed There were no Instances of severe or significant fetal Injury, although small linear "scars" were noted on four fetuses Three fetuses had abnormalities which were not related to the procedure Itself, Including spina bifida, osteogenesis Imperfecta, and congenital heart disease ... 

Neuromuscular blockade produced by succinylcholine and mivacurium can be prolonged in patients with a genetically abnormal variant of plasma cholinesterase. The dibucaine number is a measure of the ability of a patient to metabolize succinylcholine and can be used to identify at-risk patients. Under standardized test conditions, dibucaine inhibits the normal enzyme by 80% and the abnormal enzyme by only 20%. Many genetic variants of plasma cholinesterase have been identified, although the dibucaine-related variants are the most important. Given the rarity of these genetic variants, plasma cholinesterase testing is not a routine clinical procedure. 

Currently, a variety of imaging procedures are available to help detect and confirm liver metastases of extrahepatic tumors or primary hepatic tumors. The therapeutic effects of microsphere distribution, however, are not necessarily directly related to structural changes or metabolic abnormalities of the cells as detected with these imaging methods. Owing to the selective application of SIR-Spheres into the hepatic artery, the distribution of microspheres within the liver is primarily determined by hemodynamic aspects such as increased arterial perfusion of the liver metastases and low arteriovenous shunting [30]. 

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