Privileged fragment

Aronov, A.M., McClain, B., Moody, C.S. and Murcko, M.A. (2008) Kinase-likeness and Kinase-Privileged Fragments Toward Virtual Polypharmacology. Journal of Medicinal Chemistry, 51, 1214-1222. 

Gianti E, Sartori L (2008) Identification and selection of privileged fragments suitable for primary screening. J Chem Inf Model 48 2129-2139... 

Identification of additional predictive and simulation tools to leverage curated data, for example, ADMET (absorption, distribution, metabolism, elimination and toxicology). Rapid identification of privileged fragments that lead to selection of compounds of high interest for a specific target. 

Aronov AM, McClain B, Moody CS, et al. Kinase-likeness and kinase-privileged fragments Toward virtual polypharmacology. 1 Med Chem 2008 51 1214-1222. 

As a privileged fragment, quinoline is a ubiquitous subunit in many quinoline-containing natural products with remarkable biological activities [37], Members of this family have wide applications in medicinal chemistry, being used as antimalarial, anti-inflammatory, antiasthmatic, antibacterial, anti-hypertensive, and tyrosine kinase-inhibiting agents [38, 39],... 

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