Prion diseases history

A large number of point mutations have been described. Several show marked ethnogeographic clustering related to the occurrence of a mutation in a founder whose descendants migrated and increased in frequency in different geographical regions in accordance with the history of human populations. Only the common mutations that illustrate some of the key genetic aspects of inherited prion diseases are described here. 

History or ciinicai evidence of prion disease Prion disease risk factors... 

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