Primary structure The sequence

The primary structure - the sequence of peptide-bonded amino acids in the protein chain and the location of any disulfide bridges. 

Primary Structure the sequence of amino acids bonded to each other in a peptide chain... 

As the chain length increases further, other factors come into play to determine the overall conformation of the peptide and the electrically charged groups at the ends of the chain are less important in this respect. Interactions, repulsive and attractive, between side-chains are dominant and the primary structure (the sequence of the peptide and the stereochemistry at each chiral centre) determines the run of the peptide chain through the molecule (the secondary structure) and the overall shape of a single polypeptide chain (globular, extended, etc. the tertiary structure) of the molecule. 

Primary structure The sequence of the monomeric units in proteins, carbohydrates, and so on. 

Secondary structure must not be confused with the overall shape of a polypeptide. The overall shape of a polypeptide arises from the different regions of secondary structure folding upon each other and is called the tertiary structure if it involves only the same peptide or the quaternary structure if it involves two or more separate peptides. For example, the complete structure of myoglobin in Figure 6.1 arises from primary structure (the sequence of amino acids shown as numbers), the secondary structure (the 3D scheme by which the individual amino acids are arranged with respect to each other), and the tertiary structure (the way in which the secondary structures are folded together to make the globular molecule). 

Cyanogen bromide (BrC=N) causes the hydrolysis of the amide bond on the C-side of a methionine residue. Cyanogen bromide is more specific than the endopeptidases about what peptide bonds it cleaves, so it provides more reliable information about the primary structure (the sequence of amino acids). Because cyanogen bromide is not a protein and therefore does not recognize the substrate by its shape, cyanogen bromide will still cleave the peptide bond if proline is at the cleavage site. 

Secondary structure The folding pattern of a peptide chain—in contra.si to primary structure, the sequence of residues. 

Primary structure the sequence of amino acids in the polypeptide chain (see Figure 1.3). This is unique to each protein, and is determined (primarily) by the genetic information encoded in the DNA of the relevant gene. 

Primary structure The sequence of amino acids in a peptide or protein. 

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