Primary structure generation

R. A. Lewis and P. M. Dean, Proc. R. Soc. London Ser. B, 236, 125 (1989). Automated Site-Directed Drug Design The Concept of Spacer Skeletons for Primary Structure Generation. 

The preparation of polypeptide and polypeptide hybrid vesicles with predictable properties begins with proper synthesis of a primary structure. This section focuses on three different classes of procedures that are used to synthesize polypeptides. Although conjugation between the polypeptide and non-polypeptide blocks to form polypeptide hybrids is discussed briefly with the third class of synthesis procedures (Sect. 2.3), more detailed information regarding the synthesis and generation of polypeptide hybrid macromolecules are reviewed elsewhere [22-26]. 

To provide some sense of the rate of progress in biochemistry and the rate at which information is generated, Sanger got the primary structure for insuhn, a small protein, in 1955 after several years of dedicated work. We waited 8 years for the next primary structure, that for ribonuclease A, for which a Nobel Prize in Chemistfy (in part) was also awarded, in 1972 to Christian Antinsen, Sanford Moore, and William Stein. There are now tens of thousands of such structures known and the number increases substantially each and every day. The hbrary of known primary structures is collected in several major databases and is accessible to scientists or others who have need of them. ... 

Evans, R.E. and Masters, J.E. (1987). A new generation of epoxy composites for primary structural applications materials and mechanics. In Toughened Coinpo.sites, ASTM STP 937 (N.J. Johnston ed.). ASTM. Philadelphia, PA, pp 413-436. 

Nucleophilic attack at a carbocationic carbon, similar to that observed in metal -carbynes, has been observed from CNBu additions to the //2-t/2-ace-tylide in the complex Fe2(CO)6(C=CPh)PPh2 (427). The ligand dipole, indicated from the X-ray structural determination of the product 96, makes it susceptible to additions of primary amines, generating the carbene 97. 

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