Pressure filtration batch concentration system

Figure 2. Pressure filtration batch concentration system.

Routine steam sterilization is a requirement for any system of sterile filtration, and is often carried out after each batch, according to laid down procedures, although this is not absolutely necessary, provided that the filter is kept pressurized, the relative humidity is kept below recommended levels, and a small bleed of air is allowed to flow continuously. It is important to note that the sterilizing steam must be saturated and free from any additives. Dirt in the system can cause filter contamination and hence increased pressure drop, and additives also have the same effect by crystallizing on the filter medium, which may also concentrate any possible chemical effects. 

---