Prephenic acid preparation

Preparative chromatography, 6 374, 385 Preparative high performance liquid chromatography, 6 441 Prephenic acid, 2 83-84 Prepolymers, 24 705... 

The preparation of a key intermediate in an imaginative synthesis of prephenic acid is depicted below. Write a series of equations showing the important steps and intermediates in this process. Indicate the reagents required to bring about the desired... 

Prephenic acid has also been shown to be converted (by a partly purified enzyme preparation) to p-hydroxyphenylpyruvic acid. Diphosphop3rridine nucleotide was required for this reaction, suggesting oxidation of C4, followed by decarboxylation. This -prephenic dehydrogenase was missing in... 

When we began our synthetic program, shikimic acid had been prepared by a number of routes, and the groups of Danishefsky and Plieninger had reported syntheses of prephenic acid. The intervening intermediates, shikimate-3-phosphate (S-3-P), 5-enolpyruvylshikimate-3-phosphate (EPSP), and chorismate, were only available from natural sources or by enz)onatic transformations. 

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