Preparation of Polyamidoamine Dendrons

DENDRITIC MOLECULES ON SOLID SUPPORT SOLID-PHASE SYNTHESIS AND APPLICATIONS 

PAMAM dendrons were also prepared on silica, as early as 1998, by Tsubokawa et al. and by many other groups, such as Arya and Alper, Kunitake, Rhee, Bu, Kawi, Qiu, Imae, and Yang. ° Usually, 3-aminopropyl-functionalized silica was employed as the parent support. In most studies, ethylenediamine-based PAMAM was constructed via the approach developed for solution by Tomalia and pioneered on solid support by Bradley. 

The PAMAM grown on silica can be used as it jg 42a,44,s2 54 small organic or 

Alternatively, a polymer (e.g., vinyl polymer) can be grafted on the dendron termini, thus forming core-shell particles with the dendritic interface between the inorganic core and the organic outer shell.  

In a number of cases, PAMAM dendrons were also prepared on other polymer particle cores, such as alumina, chitosan, cellulose, zirconia-urea-formaldehyde resin, silica-coated magnetite, and carbon nanotubes. Like the silica support (see above), at least in the case of the chitosan, the theoretically predicted propagation of the dendrons was not achieved, presumably due to the steric hindrance in the support pores. 

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