Preparation of 3-Hydroxy-3-methyl-2-Butanone

Purpose To demonstrate the hydration of a terminal alkyne and to determine the regiochemistry of the addition. 

Concentrated sulfuric acid may cause severe chemical burns, so do not allow it to come into contact with your skin. Wear latex gloves when transferring this reagent. Wash any affected area immediately with water and then with 5% sodium bicarbonate solution. 

Be sure that you add the concentrated acid slowly to wafer and not the reverse. 

Preparation Sign in at www.cengage.com/login to answer Pre-Lab Exercises, access videos, and read the MSDSs for the chemicals used or produced in this procedure. Review Sections 2.9. 2.10. 2.11. 2.13. 2.16. 2.21. 2.22. and 2.29. 

Apparatus A 10-mL. a 50-mL. and a 100-mL round-bottom flask, separatory funnel, ice-water bath. 13-mm x 120-mm test tube, apparatus for heating under reflux, simple distillation, magnetic stirring, steam distillation with internal steam generation. vacuum filtration, and flameless heating. 

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