Preparation of 4-Bromo-2-Chloroacetanilide

Chlorine gas is evolved in this procedure. To minimize exposure to it, perform this reaction in the hood, if possible. Alternatively, invert a funnel over the reaction flask and attach the funnel to the water aspirator to remove the gaseous chlorine (Fig. 2.71 b). 

Concenfrafed hydrochloric acid and glacial acetic acid are corrosive liquids. Wear latex gloves when handling these chemicals and thoroughly wash any areas of your skin that may come in contact with them. 

Preparation Sign in at www.cengage.com/login to answer Pre-Lab Exercises, access videos, and read the MSDSs for the chemicais used or produced in this procedure. Review Sections 2.9, 2.10, 2.11, and 2.17. 

Apparatus A 250-mL round-bottom fiask, ice-water bath, apparatus for magnetic 

Setting Up Suspend 10.7 g of 4-bromoacetaniiide in a stirred solution of 23 mL of concentrated hydrochioric acid and 28 mL of giacial acetic acid contained in the round-bottom fiask. Heat the mixture gentiy with stirring untii it becomes homogeneous and then cooi the soiution to 0 °C. Prepare a soiution of 2.8 g of sodium chiorate in about 7 mL of water. 

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