Prekinamycin-Based Quinone Methides

FIGURE 7.23 Prototype diazobenzo[6]fluorene-based natural products kinamycin A and prekinamycin. Compounds prepared for this study are shown in the inset. 

CHARACTERIZING QUINONE METHIDES BY SPECTRAL GLOBAL FITTING 

The 13C-NMR spectrum of the products arising from prekinamycin reductive activation is shown in Fig. 7.3. The identity of the compounds giving rise to the 

FIGURE 7.24 Spectra obtained from spectral global fitting to the surface shown in Fig. 7.2 spectrum of quinone at zero time and the spectrum of the quinone methide intermediate. 

SCHEME 7.21 Synthesis of a stable quinone methide using rhodium (II) acetate in methanol.84,93 The 13C label is designated with an asterisk ( ). 

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