Preformulation studies salt screening

Tong, W.Q. and Whitesell, G. (1998l)n situ salt screening useful technique for discovery support and preformulation studie harm. Dev. Tech., 3, 215-223. 

Tong, W. Q., Whitesell, G. In situ salt screening — a useful technique for discovery support and preformulation studies. Pharm. Dev. Technol 1998, 3(2), 215-232. 

To comply with the concept that in preformulation studies minimal amounts of compound are used, an in situ salt screening technique for basic compounds has been developed by Tong and Whitesell (1998). The steps involved in this process are listed below ... 

Solubility is highly influenced by the solid-state form (e.g., crystalline or amorphous) of the drug. Rigorous solubility studies using the final solid form (i.e., salt form or crystal form) as a function of temperature (i.e., 25 and 37°C) and pH (range 1 to 7.5) are conducted during preformulation. Solubility in nonaqueous solvents is also screened. Solubility in simulated gastrointestinal fluids is also important. 

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