Prednisolone stearoylglycolate

Chemical Name 11/3,17-Dihydroxy-21 - [ [ [ (1 -oxoctadecyDoxy] acetyl] oxy] pregna-1,4-diene-3,20-dione 

Trade Name Manufacturer Country Year Introduced 

This material can be prepared, e.g, by reaction of prednisolone-21-chloroacetate in solvent with the sodium or potassium salt of the corresponding aliphatic or aromatic acid, or by reaction of prednisolone with the chloride of the corresponding acyl-glycolic acid, in the presence of a hydrochloric acid acceptor. 

Alternative (A) 3 grams (0.0068 mol) prednisolone chloroacetate dissolved in 200 ml tetrahydrofuran and 10 ml HjO are added with 2.7 grams (0.00B4 mol) K stearate and 

06 g Nal and heated to boiling, under stirring, for 36 hours, then evaporated in vacuum to dryness. 

Trade Name Manufaetu rer Country Year lntro  

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Table 1.1. Activity of prednisolone stearoylglycollate, corrected for prednisolone content, compared with prednisolone (activity = 1) [28]...

Two further communications [31,32] reported that prednisolone stearoylglycollate, in substantial doses, was the least potent anti-inflammatory steroid (among the representative series studied) with respect to pituitary-adrenal inhibition. The order of increasing suppressive potency in this test was prednisolone stearoylglycollate, prednisolone, triamcinolone, dexamethasone, betamethasone. Techniques used in the comparative evaluations included the metyrapone test and gas-liquid chromatography. 

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