Toxicogenomics predictive

PTS CuraGen Corporation Predictive Toxicogenomic Screen www.curagen.com/md/pts.asp... 

Fielden MR, Kolaja KL. The state-of-the-art in predictive toxicogenomics. Curr Opin Drug Discov Devel 2006 9 84-91. 

A review of case studies in the use of toxicogenomics in drug discovery reveals three main categories of application diagnostic toxicogenomics (biomarkers), predictive toxicogenomics, and mechanistic/investigative studies (Searfoss et al., 2005, Khor et al., 2006, Chen et al., 2012). In this... 

Buick, J., Moffat, L, WiUiams, A., et al. 2015. Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells. Environ. Mol. Mutagen. 56 520-534. 

Nie, A.Y., McMiUian, M., Parker, J.B., et al. 2006. Predictive toxicogenomics approaches reveal underlying molecular mechanisms of nongenotoxic carcinogenicity. Mol. Carcinog. 45(12) 914-933. 

Use of Reference Databases to Interpret Toxicogenomic Results and Predict Potential Human Toxicity... 

Suter L, Babiss LE, Wheeldon EB. Toxicogenom-ics in predictive toxicology in drug development. Chem Biol 2004 11 161-71. 

Albertini, S.S.-D.L., Ruepp, S. andWeiser, T. (2004) Toxicogenomics How predictive is toxicogenomics for toxicity in animal and man 7th International Society forthe Study ofXenobiotics Meeting, Vancouver. 

---