Preclinical Analysis of Serp

Preclinical Analysis of Serp-1 Pilot Studies—Rabbit Model 

Spi-3 protein from Vaccinia virus binds uPA and tPA, with weaker binding to fXa and plas-min as described in preceding sections. Spi- 3 was also tested in parallel with Serp-1 in a limited study after balloon angioplasty injury in rat models. Spi-3, as for Serp-1, reduced plaque growth significantly when a single injection was given i.v. after balloon injury (A. Lucas and R. Moyer, unpublished observations). 

Preclinical Animal Models Study of Inflamed Plaque in ApoE  

Serpin Sequence Target Origin No Doses Preclinical Model Findings 

Serp-1 EADERGTTAS tPA, uPA, Myxoma Wolinsky Balloon Inflammation-D, 

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