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PPARy Antagonists

It has been shown that the expression of connexin 43 (Cx43) is upregulated by cancer-preventive retinoids and carotenoids, which correlate with the suppression of carcinogen-induced transformation in 10T1/2 cells. Recently, it has been reported that Cx43 induction by astaxanthin, but not by a RAR-specific retinoid, was inhibited by GW9662, a PPARy antagonist (Bertram et al., 2005). [Pg.469]

Corticotropin-releasing factor (CRF) receptor modulators CRF antagonists may act on depression, various other neuropsychiatric disorders and immune diseases. PPARs, an essential group of nuclear receptors PPARa receptors are involved in dyslipemias, atherosclerosis and obesity PPARy receptors are mainly involved in diabetes but also in dyslipemias, hypertension, inflanunation and cancer PPARS receptors, in addition to dyslipemia control, are involved in fertility and cancer. ... [Pg.86]

Information reported by Koguro and co-workers was used by Aventis to scale up a leukotriene D4-receptor antagonist and PPARy agonist 45. Bridge et al. found that Et3NH Cr reduced the amount Et3NH 3 sublimate (in comparison to NH4CI), which was observed when NMP was used as... [Pg.286]

Table 6.1 Natural products described as PPARy agonists or antagonists... [Pg.159]

See other pages where PPARy Antagonists is mentioned: [Pg.469]    [Pg.478]    [Pg.463]    [Pg.233]    [Pg.421]    [Pg.381]    [Pg.381]    [Pg.53]    [Pg.72]    [Pg.158]    [Pg.163]    [Pg.164]    [Pg.469]    [Pg.478]    [Pg.463]    [Pg.233]    [Pg.421]    [Pg.381]    [Pg.381]    [Pg.53]    [Pg.72]    [Pg.158]    [Pg.163]    [Pg.164]    [Pg.893]    [Pg.899]    [Pg.507]    [Pg.328]    [Pg.261]    [Pg.390]    [Pg.391]    [Pg.172]    [Pg.10]    [Pg.394]    [Pg.893]    [Pg.899]    [Pg.186]    [Pg.75]    [Pg.616]    [Pg.64]    [Pg.484]    [Pg.488]    [Pg.913]    [Pg.323]    [Pg.85]    [Pg.234]    [Pg.89]    [Pg.117]    [Pg.214]    [Pg.375]    [Pg.318]    [Pg.80]    [Pg.659]    [Pg.165]    [Pg.722]    [Pg.3902]    [Pg.4118]    [Pg.156]   


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