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PPAR-RXR heterodimer

Peroxisome Proliferator-Activated Receptors. Figure 2 Binding of PPAR RXR heterodimers to DR1 PPRE-responsive elements. Abbreviations DR1, a direct repeat organization of the A/GGGTCA hexamer half-site separated by a single nucleotide spacer. [Pg.940]

Figure 9.10. Regulation of target genes by PPAR RXR heterodimers. Fatty acids serve as transcriptional inducers and substrates of enzymes involved in lipid homeostasis. (From Handschin, C., and Meyer, U. A. Induction of drug metabolism The role of nuclear receptors. Pharmacol. Rev. 55 649-673, 2003.)... Figure 9.10. Regulation of target genes by PPAR RXR heterodimers. Fatty acids serve as transcriptional inducers and substrates of enzymes involved in lipid homeostasis. (From Handschin, C., and Meyer, U. A. Induction of drug metabolism The role of nuclear receptors. Pharmacol. Rev. 55 649-673, 2003.)...
Figure 3 The PPAR family and its DNA properties, (a) The murine PPAR subfamily. The DNA and ligand-binding domains are indicated. Numbers represent percentage amino acid identity, (b) The PPARs bind to DR-1-type DNA response elements as heterodimers with RXR. The PPAR/RXR heterodimer can be activated by ligands for either PPAR or RXR. (Reproduced from Kliewer SA, Xu HE, Lambert MH, and Willson TM (2001) Peroxisome proliferator-activated receptors From genes to physiology. Recent Progress in Hormone Research 56 239-265, with permission from The Endocrine Society.)... Figure 3 The PPAR family and its DNA properties, (a) The murine PPAR subfamily. The DNA and ligand-binding domains are indicated. Numbers represent percentage amino acid identity, (b) The PPARs bind to DR-1-type DNA response elements as heterodimers with RXR. The PPAR/RXR heterodimer can be activated by ligands for either PPAR or RXR. (Reproduced from Kliewer SA, Xu HE, Lambert MH, and Willson TM (2001) Peroxisome proliferator-activated receptors From genes to physiology. Recent Progress in Hormone Research 56 239-265, with permission from The Endocrine Society.)...
Figure 11.2 PPREs serve as the binding site for the PPAR-RXR heterodimer and are composed of a direct repeat of two element half sites (AGGTCA) spaced by a single nucleotide (n). Binding of the heterodimer to the PPRE initiates transcription of specific target genes. Figure 11.2 PPREs serve as the binding site for the PPAR-RXR heterodimer and are composed of a direct repeat of two element half sites (AGGTCA) spaced by a single nucleotide (n). Binding of the heterodimer to the PPRE initiates transcription of specific target genes.
We have identified the mitochondrial 3-hydroxy-3-methylglutaiyl-CoA (HMG-CoA) synthase gene as a PPAR target, and we have found that this receptor, which mediates the induction of the gene by fatty acids, binds as a PPAR-RXR heterodimer to a... [Pg.79]

FiggK 3. Scheme of the S -flanking region of the human MCPT /. (A) The positions of exons lA, IB and 2 containing the translation initiation codon (open rectangles) and the presence of the PPRE (dashed box) are indicated. (B) Comparison of the sequence of the proposed PPRE with the consensus. (C) Electrophoretic mobility shift assay of the muscle CPTI PPRE with PPAR-RXR heterodimers. PPAR a, y and 5 and RXRa were translated in vitro, incubated with the proposed CPT I PPRE labelled probe, and analyzed by Hee-trophoretic mobility shift assay. Additions were as indicated on the top of the figure. [Pg.83]

PPARrRXR HETERODIMERS AND LIPID HOMEOSTASIS 4.1. PPAR RXR Heterodimers and PPREs... [Pg.245]

See other pages where PPAR-RXR heterodimer is mentioned: [Pg.940]    [Pg.940]    [Pg.887]    [Pg.621]    [Pg.1949]    [Pg.1950]    [Pg.515]    [Pg.371]    [Pg.371]    [Pg.374]    [Pg.378]    [Pg.82]    [Pg.82]    [Pg.82]    [Pg.245]    [Pg.246]    [Pg.232]    [Pg.82]    [Pg.82]    [Pg.82]    [Pg.245]    [Pg.246]    [Pg.246]   
See also in sourсe #XX -- [ Pg.371 , Pg.378 ]



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