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Potential protein binding interaction

Aspirin and the NSAIDs generally undergo few clinically significant pharmacokinetic interactions. The majority are highly protein bound, and have the potential to interact with other drugs via this mechanism. However, with a few exceptions, most of these interactions are not clinically important (see Protein-binding interactions , (p.3)). [Pg.133]

Ferritin, an iron-binding protein, prevents ionized iron (Fe ) from reaching toxic levels within cells. Elemental iron stimulates ferritin synthesis by causing the release of a cytoplasmic protein that binds to a specific region in the 5 nontranslated region of ferritin mRNA. Disruption of this protein-mRNA interaction activates ferritin mRNA and results in its translation. This mechanism provides for rapid control of the synthesis of a protein that sequesters Fe +, a potentially toxic molecule. [Pg.370]

The administration of cloflbrate to a patient taking warfarin will potentiate the anticoagulant effect of warfarin by displacing It from Its protein binding site (7). This Interaction will cause... [Pg.277]

Another potential mechanism for protein retention is that ER proteins bind to each other to form large complexes that cannot be recruited in transport vesicles [27], This mechanism is known as kin recognition. Because the concentration of resident ER proteins can be very high (some had been estimated in the millimolar range), it can be achieved even with low-affinity interactions among resident proteins. [Pg.146]


See other pages where Potential protein binding interaction is mentioned: [Pg.3034]    [Pg.3034]    [Pg.1308]    [Pg.26]    [Pg.32]    [Pg.337]    [Pg.343]    [Pg.344]    [Pg.367]    [Pg.277]    [Pg.420]    [Pg.1308]    [Pg.318]    [Pg.129]    [Pg.181]    [Pg.472]    [Pg.35]    [Pg.1303]    [Pg.422]    [Pg.453]    [Pg.296]    [Pg.177]    [Pg.293]    [Pg.103]    [Pg.1029]    [Pg.9]    [Pg.52]    [Pg.69]    [Pg.180]    [Pg.155]    [Pg.467]    [Pg.500]    [Pg.312]    [Pg.901]    [Pg.925]    [Pg.926]    [Pg.296]    [Pg.63]    [Pg.187]    [Pg.203]    [Pg.459]    [Pg.235]    [Pg.7]    [Pg.81]    [Pg.330]    [Pg.68]   
See also in sourсe #XX -- [ Pg.3034 ]




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Binding potential

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