Potential Functions of Calmodulin-Kinase II in Smooth Muscle

POTENTIAL FUNCTIONS OF CALMODULIN-KINASE II IN SMOOTH MUSCLE 

Phosphorylation of caldesmon in vitro by CaM-kinase II (or PKC) has been shown to interfere with caldesmon binding to F-actin, and results in a reversal of the caldesmon inhibitory effect on actin-activated myosin ATPase activity (Ngai and Walsh, 1987). This has led to speculation that these kinases may be in- 

HAROLD A. SINGER, S. THOMAS ABRAHAM, AND CHARLES M. SCHWORER 

Bhagat, B., and Palfrey, C. (1985). Proc. Natl. Acad. Sci. 

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