Potato serine protease inhibitors

Pouvreau, L., Gruppen, H., van Koningsveld, G. A., van den Broek, L. A. M., Voragen, A. G. J. (2003). The most abundant protease inhibitor in potato tuber (cv. Elkana) is a serine protease inhibitor from the Kunitz family. J. Agric. Food Chem., 51, 5001-5005. 

Solanum (potato) Kunitz PEPs inhibit the aspartic protease cathepsin D as well as trypsin [125-134] and potato cysteine protease inhibitor (PCPI) inhibits a variety of cysteine proteases [185-188]. The crystal structures of soybean trypsin inhibitor (STI) [362, 368] and of Erythrina trypsin inhibitor (ETI) [350] have been determined. The structure of this type of plant Kunitz serine PIP involves a [3-barrel formed by 6 loop-linked antiparallel [3-strands with a lid formed by 6 further loop-linked antiparallel [3-strands. The scissile bond is located within a loop that extends out from the surface of the [3-barrel [350, 362, 368]. 

Table 13. Potato Type I serine protease inhibitors...

Arabidopsis tlialiana (mouse-ear cress) (Brassicaceae) Arabidopsis genes encoding - 8 kDa Potato type 1 serine protease inhibitors Trypsin (inferred) [438]... 

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