Potassium Competitive Acid Blockers

Potassium Competitive Acid Blockers The pregnane X receptor (PXR) is a promiscuous nuclear receptor, that has evolved to protect the body from toxic chemicals. It is activated by a wide variety of xenobiotics including several diugs like rifampicin, hyperforin ( the active ingredient of St. John s wort), clotrimazole and others. PXR heterodimerizes with the... 

Gastric H,K-ATPase inhibitors Potassium competitive acid blockers... 

Poor Metabolizer Phenotype Population Pharmacokinetics Positron Emission Tomography Post-translational Modification Potassium Channels Potassium Competitive Acid Blockers PP... 

A number of bench-scale processes with Ru/P P/N N catalysts are summarized in Fig. 13. Dow/Chirotech [91] used Ru/Xyl-PhanePhos/dpen for the hydrogenation of p-fluoro acetophenone. Kanto Chemicals developed a very effective Ru/bdpp/N N catalyst (the only case where the diphosphine is not a biaryl type) and applied it to the large scale hydrogenation of acetophenone [92] and of a quinuclidine [93] for a muscarinic receptor antagonist. Nycomed/JMC [94] scaled up the hydrogenation of rather complex ketone intermediate for the synthesis of a potassium competitive acid blocker. 

Palmer AM, Grohhel B, Jecke C, Brehm C, Zumnermann PI, Buhr W, Feth MP, Simon W-A, Kromer W. Synthesis and evaluation of 7JS-8,9-dihydropyrano[2,3-c]imidazo[l,2-a] pyridines as potassium-competitive acid blockers. J. Med. Chem. 2007 50(24) 6240-6264. 

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