Post-Ugi cyclization

Fig. 5 Post-Ugi cyclization driven by nucleophilic afkyl substitutions where the isocyanide-derived amide serves as nucleophile...

Fig. 24 Cyclic imines/enamines from post-Ugi cyclization of amino ketones or amino aldehydes...

New synthetic methods for benzodiazepine synthesis involving Ugi-type multicomponent/post-Ugi cyclization reactions continue to be of interest. Ugi reactions of indole-2-carboxaldehydes, isocyanides, amines, and 2-iodobenzoic acid derivatives led to intermediates which, with copper(I) catalysis, underwent intramolecular indole N-arylation to produce indolo-fused benzodiazepinones, such as 134 (13CC2894). 2-Azido-benzaldehyde, isocyanides, propargylamines, and nitrophenols underwent Ugi-type reaction, Smiles-type rearrangement, and intramolecular azide-alkyne cyclization to afford triazolo-fused benzodiazepinones such as 135... 

---

See also in sourсe #XX -- [ ]

---