Post-synthetic modification grafting

In summary, aliphatic polyesters, already an important class of synthetic degradable polymeric biomaterials, have been taken to unprecedented levels of synthetic diversity and tailoring through the efforts of many research groups in the U.S. and abroad. Some of these have been described in this brief review, with a focus on pendent or graft functionality by polymerization of functionalized lactones, and post-polymerization modification. Future efforts in this area must attempt to connect these synthetic advances to specific applications, through the collaborative efforts of experts in the chemistry, biology, and clinical use of synthetic polymer materials. 

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