Porogen ordered porosity

Additionally, TADDOL derivative (9) which contained an additional styrene group was first prepared in solution and then underwent bulk polymerization in the presence of various porogenic agents in order to obtain soHd-phase-bound catalyst (10) with the desired porosity (Scheme 4.5) [67]. 

The resulting porosity of the monolithic polymer is thus defined as the space inside the polymer being occupied by porogens and—in case of uncomplete monomer conversion—nonreacted monomer as well as cross-linker. Consequently, the overall porosity is composed by three different contributions (listed in their chronological order of development during polymerization and in the order of increasing mean pore size) ... 

The performance of the molecularly imprinted monolith in terms of molecular recognition and flow-through properties depends on several factors, especially the density and the porosity of the polymer. In order to obtain a monolith with high selectivity and high permeability, some preparation conditions must be optimised, in particular the composition of the prepolymerisation mixture including the amount of template, the type and amount of functional monomer, crosslinker, porogenic solvent and the initiator, and the polymerisation conditions such as initiation process and polymerisation time. 

In addition to the fabrication of porous polymers, TIPS can be used in order to produce scaffolds with a nanofibrous morphology, with fibre diameters generally ranging from 50 nm to 500 nm with porosities up to Such nanofibrous architectures are believed to more closely mimic the native ECM environment. Combining phase separation with the addition of a porogen, such as paraffin spheres, yields macroporous... 

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