Pork regular insulin

Pork regular and isophane insulin (in a ratio of 30 70 RAPIMIX) 40 U/ml... 

Beef regular Iletin 11 Pork regular Iletin 11 Regular purified pork insulin Human (purified)... 

The graph in Fig. 2 can be used to address the most fundamental question regarding insulin iontophoresis—is it theoretically possible, under the most favorable conditions, to deliver the required dose Based on the discussion in Section 2.1, the needs are a basal delivery rate of 1-2 units per hour coupled with a bolus of up to 20 units over about a half-hour. Figure 2 indicates that a delivery rate of 40 units per hour could be achieved with a 1 mM solution of insulin, which is equivalent to about 4mg/ml or 100 units/ml. Regular (currently marketed human, pork, or beef) insulin has a water solubility that exceeds this value. Thus, it is theoretically possible to iontophorese insulin at the required rate. However, an idealized model has been used to reach this conclusion. Specifically, it was assumed that insulin exists as an ideal solution (with a MW of 5800), that the mobility of insulin is independent of pH and has a value close to its maximum value, and that the molecule is not degraded on its way through the skin. For regular insulins, these assumptions are not true. In the next section, the physicochemical properties of insulin that impact its deliverability by iontophoresis are described. 

For regular insulin, such as beef, pork, or human insulin, the prospects for iontophoretic delivery seem quite poor. In spite of the attractiveness of the concept, there is not a single publication reporting success. Indeed, Stephen eta/. (1984) reported failure. 

Make any change of insulin cautiously and only under medical supervision. Changes in purity, strength, brand (manufacturer), type (eg, regular, NPH, lente), species (beef, pork, beef-pork, human), or method of manufacturer (rDNA vs animal-source insulin) may result in the need for a change in dosage. 

Rapid-acting Insulin injection USP (regular, crystalline zinc) Human, pork 0.5-3 5-7... 

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