Porcine malignant hyperthermia

Harrison, G.G. (1979). Porcine malignant hyperthermia. Inti. Anesthesiol. Clin. 17, 25-62. 

Maccani, R. M., Wedel, D. J., and Hofer, R. E. (1996). Norepinephrine Does Not Potentiate Porcine Malignant Hyperthermia. Anesth Analg 82(4) 790-5. 

Nelson, T. E. (1990). Porcine Malignant Hyperthermia Critical Temperatures for in Vivo and in Vitro Responses. Anesthesiology 73(3) 449-54. 

Otsu K, Khanna VK, Archibald AL, MacLennan DH. Cosegregation of porcine malignant hyperthermia and a probable causal mutation in the skeletal muscle ryanodine receptor gene in backcross families. Genomics 1991 11(3) 744-750. 

Tonner, P.H., Scholz, J., Richter, A., Loscher, W., Steinfath, M., Wappler, F., Wlaz, P., Hadji, B., Roewer, N., and Schulte am Esch, J., 1995, Alterations of inositol polyphosphates in skeletal muscle during porcine malignant hyperthermia. Br. J. Anaesth. 75 467 471. 

Otsu, K., Phillips, M.S., Khanna, V.K., de Leon, S., MacLennan, D.H. (1992). Refinement of diagnostic assays for a probable causal mutation for porcine and human malignant hyperthermia. Genomics 13, 8325-837. 

Malignant hyperthermia also occurs in swine. Susceptible animals homozygous for malignant hyperthermia respond to stress with a fatal reaction (porcine stress syndrome) similar to that exhibited by humans. If the reaction occurs prior to slaughter, it affects the quality of the pork adversely, resulting in an inferior product. Both events can result in considerable economic losses for the swine industry. 

Fujii J, Otsu K, Zorzato F, De Leon S, Khanna V K, Weiler J E, O Brien P J and MacLennan D H (1991), Identification of a mutation in the porcine ryanodine receptor associated with malignant hyperthermia , Science, 253, 448-451. 

HT2 receptors are present on skeletal muscle membranes, but their physiologic role is not understood. Malignant hyperthermia is a condition precipitated by certain anesthetic and neuromuscular agents that results in severe hyperthermia due to skeletal muscle overactivity and metabolic and autonomic instability. In a genetic porcine model of this condition, administration of... 

---