POMERANZ-FRITSCH-SCHLITTER-MULLER

POMERANZ - FRITSCH SCHLITTER MULLER I soquinoDna Synthesis... [Pg.303]

POLONOVSKY N Oxide re POMERANZ FRITSCH SCHLITTER MULLER Isoquinoline synthesis 303 Ponndoif 251... [Pg.226]

Isoquinoline synthesis from aromatic aldehydes or benzyl halides and aminoacetal (Pomeranz-Fritsch) or from benzylamines and glyoxal acetal (Schlitter-Muller) (see 1st edition). [Pg.292]

The Pomeranz-Fritsch reaction involves the initial condensation of an aryl aldehyde with 2-aminoaldehyde acetal to provide aldimine, which is then isolated and cyclized under strong acid conditions to afford the isoquinoline framework. The most known variation of this reaction is using benzylamine and glyoxal diethylacetal as the coupling pair for the initial condensation (known as the Schlitter-Muller variation), which is able to provide 1-substituted isoquinolines. ... [Pg.521]

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