Polyvinylpyrrolidone /sucrose formulations

Aso Y, Yoshioka S, Zhang J, Zografi G. Effect of water on the molecular mobility of sucrose and polyvinylpyrrolidone) in a colyophilized formulation as measured by 13C NMR relaxation time. Chem Pharm Bull 2002 50 820-826. 

Table 2 gives some examples of excipients used as stabilizers for proteins in freeze-dried formulations. Among others, saccharides are the most widely used excipients for stabilizing freeze-dried therapeutic proteins. There are exceptions to the need for stabilizing excipients, e.g., recombinant (ot-Antitrypsin was stable when freeze-dried alone or with lactose, sucrose, and polyvinylpyrrolidone. ... 

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