Polyvinylpyrrolidone blood plasma substitute

Soluble polyvinylpyrrolidone was first used during World War II as a blood-plasma substitute. Although it has excellent properties for this purpose, it has no longer been used for a number of decades. The organism does not metabolize the polymer, with the result that after parenteral administration, small quantities of high-molecular components may remain within the body. This problem does not exist with oral administration. 

The only other polymer that has been included in some studies was polyvinylpyrrolidone), PVP, used as a blood plasma substitute. It is also adsorbed on the silica surface but is generally a less effective antagonist for silica, possibly because it is less strongly adsorbed. 

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