Polyurea dendron

Scheme 15.14. Synthesis of polyurea dendrons on solid support.

Another two types of supported dendrons used for generation of dendritic gene delivery devices are the polystyrene-bound polyurea and peptoid dendrons developed by Bradley and coworkers. They demonstrated that these dendrons, once cleaved from the support, complex efficiently plasmid DNA and transfect it successfully into cells. The highest efficiency (comparable or better than that displayed by the commercial transfection agent Superfect) was observed for bis-G3 dendrons capped with lysine. In general, the efficiency increased with the dendron generation (positive effect). 

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