Polythioether dendron

Another application of the rearrangement in dendrimers focuses on the development of novel polythioether dendrons on a solid support for supported catalysis applications [94]. 

Scheme 15.20. Synthesis of polythioether dendrons on solid support.

Polythioether dendrons, the sulfur analogues of the poly(aryl benzyl ether) dendrons, were assembled by Portnoy and coworkers to the fourth generation. These dendrons were prepared using the protected thiophenol monomer building block, which can be efficiently synthesized from the hydroxy isophthalate diester in multigram quantities. The deprotection of the thiophenolate performed in situ is followed by three steps (similar to those previously described for the polyether dendrons in Scheme 15.17b) for each generation assembly (Scheme 15.20). ... 

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