Polythiazide

Chemical Name 6-Chloro-3,4-dlhydro-2-methyl-3-( ((2,2,2-trifluoroethyDthiol methyl] -2H-1,2,4-benzothiadlazine-7-sulfonamide-1,1 -dioxide 

Trade Name Manufacturer Country Year introduced 

4-Amino-2-chloro-5-(methylsulfamyl)benzenesulfOnamide Manufacturing Process 

The resulting reddish mixture is refluxed on a steam bath for one hour. One half of the alcohol is removed by concentration and the remainder diluted with several volumes of water and extracted with ether. The combined ether extracts are dried over sodium sulfate, the ether then removed at reduced pressure and the residue distilled to about 30 g (BP 82°C/25 mm). 

Chemical Abstracts Registry No. 346-18-9 Trade Name Manufacturer 

4-Amino-2-chioro-5-(methyisuifamyl)benzenesuifonamide Manufacturing Process 

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Polythia six-membered ring systems, 3, 1039-1086 Polythiazides as diuretic, 1, 174 Polythiiranes, 7, 182 Polytopal rearrangements phosphoranes, 1, 529-530 rules, 1, 530 Polyurethanes curing agents... 

Duration varies with drug used. Average duration is 12—24 h with polythiazide and chlorthalidone. Indapamide has a duration of more than 24 h. 

Metatensin Tablets—trichlormethiazide, reserpine Minizide—polythiazide, prazosin Prinzide—hydrochlorotliiazide, lisinopril Rauzide Tablets—rauwolfia, bendroflumethiazide Regroton—chlorthalidone, reserpine Salutensin Tablets—hydroflumethiazide, reserpine Salutensin-Demi—hydrochlorothiazide, reseqiine Ser-Ap-Es—hydrochlorotliiazide, reseqiine, hydralazine HC1... 

Polythiazide, molecular formula and structure, 5 163t Polythiazyl, 23 654... 

In medical practice, the most frequently used are hydrochorthiazide, chorthiazide, ben-thiazide, bendroflumethiazide, hydroflumethiazid, polythiazide, trichlormethiazide, as well as related thiazides, but not those named chlortalidon, metolazone, and indapamide. 

Polythiazide Polythiazide, 1,1-dioxide 2-methyl-3-(2,2,2-trifluoroethylthiomethyl)-6-chloro-3,4-dihydro-2H-l,2,4-benzothiadiazin-7-sulfonamide (21.3.8), is also synthesized by an analogons scheme, which is by condensing 4-aminosulfonyl-5-chloro-2-methyl-aminosnlfonylaniline (21.3.7) with 2,2,2-trifluoroethylthioacetaldehyde dimethy-lacetal [22]. 

Polythiazide exhibits a more pronounced antihypertensive effect than chlorothiazide and it may be used independently for the same indications as the aforementioned drugs. However, it is primarily used as an ingredient of a combination drugs intended for lowering pressure, in particnlar in minizide, which is a combination of prazozine and polythiazide. Synonyms of this drug are drenusil, nephril, renis, and others. 

Thiazide diuretics consist of two distinct groups those containing a benzothiadiazine ring, such as hydrochlorothiazide and chlorothiazide, referred to as thiazide diuretics, and those that lack this heterocyclic structure but contain an unsubstituted sulfonamide group. The latter are called thiazidelike diuretics they include metolazone, xipamide, and indapamide. The major thiazide and thiazidelike drugs available in the United States are bendrofiumethiazide, benzthiazide, chlorothiazide, hydrochlorothiazide, hydroflumethiazide, methyclothiazide, polythiazide, and trichlormethiazide and chlorthalidone, indapamide, metolazone, and quinethazone, respectively. 

Do not use the fixed combination of prazosin/polythiazide in the initial management of hypertension. 

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