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Polyrotaxanes drug carrier

The aqueous solubility of CD also enables their potential application as poly-rotaxane-based drug carriers. Yui and coworkers incorporated CD onto PEO chains in polypseudorotaxanes and polyrotaxanes [92-94], The releasing kinetics of CD from the polymer chain were studied. The release was governed by the inclusion complexation equilibrium. Biodegradation to cleave the BG units was shown to cause the release of the CD from the polyrotaxanes. [Pg.314]

T. Ooya and N. Yui, Synthesis and characterization of biodegradable polyrotaxane as a novel supramolecular-structured drug carrier,/. Biomat. Sci. -Polym. E., 8,437-455 (1997). [Pg.69]

Ooya, T. and Yui, N. (1999) Polyrotaxanes Synthesis, structure, and potential in drug delivery. Critical Rev. Therapeutic Drug Carrier Systems, 16, 289-330. [Pg.86]

In order to examine the drug release property of the polyrotaxane micelle system, amphotericin B (AmB) was selected as a model dmg to evaluate the potential of the resulting amphiphilic PR-containing triblock copolymers as carriers for the controlled release. AmB is a broad-spectmm chemotherapy and organ antifungal therapy for the treatment of systemic transplantation, but an ahphatic water-insoluble... [Pg.225]

See other pages where Polyrotaxanes drug carrier is mentioned: [Pg.58]    [Pg.26]    [Pg.233]    [Pg.86]    [Pg.86]    [Pg.76]    [Pg.77]    [Pg.78]    [Pg.88]    [Pg.274]    [Pg.207]    [Pg.225]    [Pg.245]    [Pg.301]   
See also in sourсe #XX -- [ Pg.314 ]



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