Polyribonucleic acids

This entire subject is a very difficult one because of the complex substances the human body contains. The peptides have been attacked via study of simple model compounds, and the techniques of polymer science are being used. The same approach may be useful for other types of compounds now that synthetic polyribonucleic acids and polyelectrolytes are being made. The latter include charged side chains and thus resemble biocolloidal molecules (1086). 

Besides a source of energy, organisms require a source of materials for biosynthesis of cellular matter and products in cell operation, maintenance and reproduction. These materials must supply all the elements necessary to accomplish this. Some microorganisms utilize elements in the form of simple compounds, others require more complex compounds, usually related to the form in which they ultimately will be incorporated in the cellular material. The four predominant types of polymeric cell compounds are the lipids (fats), the polysaccharides (starch, cellulose, etc.), the information-encoded polydeoxyribonucleic acid and polyribonucleic acids (DNA and RNA), and proteins. Lipids are essentially insoluble in water and can thus be found in the nonaqueous biological phases, especially the plasma and organelle membranes. Lipids also constitute portions ofmore complex molecules, such as lipoproteins and liposaccharides. Lipids also serve as the polymeric biological fuel storage. 

Purine nucleosides are oxidized much more slowly. Adenosine can be converted to the corresponding glycosiduronic acid, but guanosine is very diflficult to oxidize. These experiments were carried out to obtain optimal conditions for the application of catalytic oxidation to polyribonucleosides and polyribonucleic acids. 

CHATTERJEE, N.K., BACHRACH, H.L. and POLATNICK, J. Foot-and-mouth disease virus ENA - presence of a 3 -terminal polyribonucleic acid and absence of amino acid binding ability. Virology, (1976), 63., 369-377-... 

The search for the best estimate of the effective hydrodynamic volume for biopolymers in SEC, which usually can be described as roughly spherical (proteins), long rods (viruses) or random-coil structures (polysaccharides and single stranded polyribonucleic acids), has led to the investigation of Rg, the solute radius of gyration in solution (ref. 11), and other related parameters. (See section 2.3). 

Polyribonucleic acids can be measured in aqueous solution using the windows at 1750-1550 cm "i. In contrast to the monomers, which do not show VCD in this region, the dimers and higher polymers show bisignate VCD bands. The spectra have been calculated for the dimers ApA and CpC using the coupled oscillator model. 

---

See also in sourсe #XX -- [ ]

---