Polypropionate fragments diastereoselective

In another report, Panek and Jain used chiral allylsilane methodology for construction of C1-C17 polypropionate fragment of ru-tamycin B and oligomycin C. The aldehyde partner used for the sequence consisted of a diol protected as a di-f-butylsilylene 18. The reaction proceeded in the presence of TiCU in excellent diastereoselectivity and yield (eq 9). 

SCHEME 10.50. Diastereoselective hetero-Diels-Alder approach to polypropionate fragments. 

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