Polyprenols reductase

The importance of the reduction of polyprenol to dolichol, catalyzed by polyprenol reductase, is clear from the study of Chinese hamster ovary (CHO) cells that lack polyprenol reductase activity [8]. These cells only synthesize polyprenol and utilize polyprenol rather than dolichol for oligosaccharyl lipid and for the various... 

The result of a lack of polyprenol reductase activity is that glycosylation of N-linked proteins is altered. Both non-glycosylation of certain sites and altered mature structures on certain sites of A -linked glycoproteins are observed in these mutants... 

Grange and Adair73 isolated 2,3-dehydrodolichyl phosphate from in vitro studies on hen oviduct. It may be derived from 2,3-dehydrodolichyl diphosphate, a likely intermediate in the biosynthesis of dolichyl phosphate. Many questions still remain unanswered, such as is the substrate for the a-isoprene reductase, the diphosphate or the monophosphate of 2,3-dehy-drodolichol Are the unsaturated polyprenols a reserve pool for the synthesis of dolichol in plants What is the function of unsaturated, plant polyprenols How is the synthesis of saturated and unsaturated polyprenols regulated ... 

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